Pub. Date : 2008 Dec 18
PMID : 19094200
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence pain sensitivity in human experimental pain and the efficacy for morphine in cancer pain treatment. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 2 | In this study we wanted to investigate if variability in other regions in the COMT gene also contributes to interindividual variability in morphine efficacy. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 3 | CONCLUSION: This study suggests that genetic variability in the COMT gene influence the efficacy of morphine in cancer patients with pain, and that increased understanding of this variability is reached by expanding from analyses of single SNPs to haplotype construction and analyses. | Morphine | catechol-O-methyltransferase | Homo sapiens |