Title : Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase.

Pub. Date : 2009 Jan

PMID : 19082897






3 Functional Relationships(s)
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1 Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase. Genistein tumor necrosis factor Homo sapiens
2 Here, we investigated whether genistein protects vascular endothelial cells against apoptosis induced by tumor necrosis factor-alpha. Genistein tumor necrosis factor Homo sapiens
3 We show that genistein significantly inhibited TNF-alpha-induced apoptosis in human aortic endothelial cells as determined by caspase-3 activation, 7-amino actinomycin D staining, in situ apoptotic cell detection and DNA laddering. Genistein tumor necrosis factor Homo sapiens