Title : Identification of a novel haplotype of the human catechol-O-methyltransferase gene.

Pub. Date : 2009 Jan

PMID : 19077667






1 Functional Relationships(s)
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1 Kinetic analysis showed that these new COMT variants had essentially the same kinetic characteristics and catalytic activity as the wild-type COMTs for the O-methylation of 2-hydroxyestradiol and 4-hydroxyestradiol in vitro, but they have a significantly reduced thermostability at 37 degrees C. 2-hydroxyestradiol catechol-O-methyltransferase Homo sapiens