Pub. Date : 2009 Mar
PMID : 19074529
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In terms of the mechanism of inhibition, 6-hydroxyflavone was found to be a noncompetitive inhibitor of CYP2C9, whereas the other flavonoids were competitive inhibitors. | 6-hydroxyflavone | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Computer docking simulation and constructed mutants substituted at residue 100 of CYP2C9.1 indicate that the noncompetitive binding site of 6-hydroxyflavone lies beside Phe100, similar to the reported allosteric binding site of warfarin. | 6-hydroxyflavone | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |