Title : Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages.

Pub. Date : 2008

PMID : 19066129






3 Functional Relationships(s)
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1 Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. amentoflavone caspase 3 Mus musculus
2 Furthermore, amentoflavone showed inhibitory effect on bcl-2 expression and upregulated p53 and caspase-3 gene expression in B16F-10 melanoma cells. amentoflavone caspase 3 Mus musculus
3 In conclusion, the observed results suggests that, amentoflavone stimulates apoptosis by regulating bcl-2, Caspase-3 and p53 genes in B16F-10 melanoma cells and regulates nitric oxide and proinflammatory cytokine production in B16F-10 cells, TAMs and peritoneal macrophages. amentoflavone caspase 3 Mus musculus