Pub. Date : 2009 Mar 13
PMID : 19056730
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Arsenite suppresses UVR-induced PARP-1 activation in a concentration-dependent manner. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 6 | PARP-1 is a zinc finger protein, and mass spectrometry analysis reveals that arsenite can occupy a synthetic apopeptide representing the first zinc finger of PARP-1 (PARPzf). | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 7 | PARP-1 is a zinc finger protein, and mass spectrometry analysis reveals that arsenite can occupy a synthetic apopeptide representing the first zinc finger of PARP-1 (PARPzf). | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 8 | Addition of Zn(II) abolished arsenite enhancement of UVR-stimulated 8-OHdG generation and restored PARP-1 activity. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 9 | Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 10 | Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 11 | Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 12 | Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 13 | Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 14 | Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |