Title : Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70.

Pub. Date : 2008 Dec 1

PMID : 19046449






2 Functional Relationships(s)
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1 Western blotting showed a reduction in proapoptotic protein Bax in the cytoplasm and mitochondria of resveratrol-treated cells. Resveratrol BCL2 associated X, apoptosis regulator Rattus norvegicus
2 CONCLUSION: In vitro protection of retinal cells from apoptosis by resveratrol occurred through multiple early molecular events, such as reduction of intracellular calcium levels, down-regulation of Bax, up-regulation of Sirt1 and Ku70 activities, and inhibition of caspase-3 activity. Resveratrol BCL2 associated X, apoptosis regulator Rattus norvegicus