Title : Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.

Pub. Date : 2009 Jan

PMID : 19028702






1 Functional Relationships(s)
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1 Treatment with 3-keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)-cyclopamine induced cancer cell apoptosis, suppressed cell growth, mobility and invasiveness and induced cancer cell dedifferentiation with decreased expression of E-cadherin, cytokeratin 7, Snail, calretinin, vimentin, Bcl-2, caspases, beta1 integrin, MT1-MMP and VEGF. 3-keto-n-(aminoethyl-aminocaproyl-dihydrocinnamoyl)-cyclopamine vimentin Homo sapiens