Title : Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine.

Pub. Date : 2009 May

PMID : 19020498






3 Functional Relationships(s)
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1 Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
2 We found that chronic duloxetine treatment was able to modulate the rapid transcriptional changes of BDNF isoforms produced by an acute swim stress. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
3 Indeed whereas the mRNA levels of BDNF exon IV were upregulated by stress in vehicle as well as in duloxetine-treated rats, a significant increase of exon VI and exon IX was only found in rats that were pretreated with the antidepressant. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus