Title : Advanced oxidation protein products induce mesangial cell perturbation through PKC-dependent activation of NADPH oxidase.

Pub. Date : 2009 Feb

PMID : 19019916






2 Functional Relationships(s)
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1 Challenge with AOPPs triggered cytosolic superoxide generation, resulting in upregulation of fibronectin and collagen IV genes and proteins and overexpression of TGF-beta1 via a PKC-NADPH oxidase-dependent pathway, as these downstream events were blocked by the inhibitors of PKC, inhibitors of NADPH oxidase, or the cytosolic superoxide scavenger. Superoxides protein kinase C, alpha Rattus norvegicus
2 Challenge with AOPPs triggered cytosolic superoxide generation, resulting in upregulation of fibronectin and collagen IV genes and proteins and overexpression of TGF-beta1 via a PKC-NADPH oxidase-dependent pathway, as these downstream events were blocked by the inhibitors of PKC, inhibitors of NADPH oxidase, or the cytosolic superoxide scavenger. Superoxides protein kinase C, alpha Rattus norvegicus