Title : Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha.

Pub. Date : 2009 Dec

PMID : 19002577






2 Functional Relationships(s)
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1 Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha. Tamoxifen BCL2 apoptosis regulator Homo sapiens
2 Antiestrogen (Tamoxifen and ICI 182,780) treatment increased Bcl-2 levels in both MCF-7 and -7B cells and led to the formation of acinar structures. Tamoxifen BCL2 apoptosis regulator Homo sapiens