Title : Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.

Pub. Date : 2009 Mar

PMID : 19002567






1 Functional Relationships(s)
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1 CONCLUSION: The antidiabetic effect of metformin may be diminished in diabetic patients with EE cholestasis, due to impaired hepatic uptake of the drug via OCT1. Metformin solute carrier family 22 member 1 Homo sapiens