Pub. Date : 2008 Dec 19
PMID : 18957427
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, the expression of dominant-negative Rab5, unable to exchange GDP for GTP, interfered with the agonist-induced dissociation of Rab5 from the syndecan-1 cytoplasmic domain and significantly inhibited syndecan-1 shedding induced by several distinct agonists. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 2 | Based on these data, we propose that Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |