Title : Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.

Pub. Date : 2008 Nov 11

PMID : 18955668






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Sorafenib prevented phosphorylation of Raf-1 and suppressed activation of the downstream ERK1/2 signaling pathway in RV myocardium and the lungs. Sorafenib mitogen activated protein kinase 3 Rattus norvegicus