Pub. Date : 2009 Feb
PMID : 18941467
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). | Dihydrotestosterone | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). | Dihydrotestosterone | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | Effects of DHT on COX-2 and iNOS were attenuated by flutamide. | Dihydrotestosterone | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | In conclusion, activation of the NFkappaB-mediated COX-2/iNOS pathway by the selective androgen receptor agonist, DHT, results in a state of vascular inflammation. | Dihydrotestosterone | nitric oxide synthase 2 | Rattus norvegicus |