Pub. Date : 2008 Oct
PMID : 18928584
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effects of proteasome inhibitor bortezomib on NF-kappaB activity and ICAM-1 mRNA expression of K562 cells]. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | This study was aimed to investigate the effects of proteasome inhibitor bortezomib (Velcade, PS-341) on the activation of NF-kappaB and the expression of intercellular adhesion molecule-1 (ICAM-1) in K562 cells. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | This study was aimed to investigate the effects of proteasome inhibitor bortezomib (Velcade, PS-341) on the activation of NF-kappaB and the expression of intercellular adhesion molecule-1 (ICAM-1) in K562 cells. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | This study was aimed to investigate the effects of proteasome inhibitor bortezomib (Velcade, PS-341) on the activation of NF-kappaB and the expression of intercellular adhesion molecule-1 (ICAM-1) in K562 cells. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | The results showed that the activation of NF-kappaB and the expression of ICAM-1 in K562 cells decreased significantly after bortezomib treatment. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | It is concluded that proteasome inhibitor bortezomib downregulates the expression of K562 cell ICAM-1 by inhibiting the activity of NF-kappaB, which provides a new way for the target therapy in acute leukemia. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |