Title : The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

Pub. Date : 2009 Jan 2

PMID : 18927074






1 Functional Relationships(s)
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1 Here we show that clioquinol inhibits the activity of mammalian CLK-1 in cultured cells, an inhibition that can be blocked by iron or cobalt cations, suggesting that chelation is involved in the mechanism of action of clioquinol on CLK-1. Cobalt CDC like kinase 1 Homo sapiens