Title : Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior.

Pub. Date : 2009 Mar

PMID : 18923403






2 Functional Relationships(s)
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1 The antidepressant desipramine inhibits the reuptake of norepinephrine (NE), leading to activation of both pre- and postsynaptic adrenergic receptors, including alpha-1, alpha-2, beta-1, and beta-2 subtypes. Desipramine hemoglobin, beta adult major chain Mus musculus
2 In addition, desipramine (3-30 mg/kg) produced an antidepressant-like effect on behavior under a DRL 36-s schedule in mice deficient in both beta-1 and beta-2 adrenergic receptors. Desipramine hemoglobin, beta adult major chain Mus musculus