Title : Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation.

Pub. Date : 2009 Feb

PMID : 18922879






3 Functional Relationships(s)
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1 In the present study, structurally diverse coenzyme-substrate derivatives mimicking this type for pyridoxal 5"-phosphate-dependent human ornithine decarboxylase (hODC), a potential anticancer target, were designed, synthesized, and tested to elucidate the structural requirements for optimal inhibition of intracellular ODC as well as of tumor cell proliferation. Pyridoxal Phosphate ornithine decarboxylase 1 Homo sapiens
2 In the present study, structurally diverse coenzyme-substrate derivatives mimicking this type for pyridoxal 5"-phosphate-dependent human ornithine decarboxylase (hODC), a potential anticancer target, were designed, synthesized, and tested to elucidate the structural requirements for optimal inhibition of intracellular ODC as well as of tumor cell proliferation. Pyridoxal Phosphate ornithine decarboxylase 1 Homo sapiens
3 In the present study, structurally diverse coenzyme-substrate derivatives mimicking this type for pyridoxal 5"-phosphate-dependent human ornithine decarboxylase (hODC), a potential anticancer target, were designed, synthesized, and tested to elucidate the structural requirements for optimal inhibition of intracellular ODC as well as of tumor cell proliferation. Pyridoxal Phosphate ornithine decarboxylase 1 Homo sapiens