Pub. Date : 2008 Nov
PMID : 18854776
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The aim of this study was to investigate whether the SLCO1B1*1B haplotype affects the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | Plasma repaglinide and nateglinide and blood glucose concentrations were measured for 7 h. RESULTS: The AUC(0-infinity) and Cmax of repaglinide were 32% (P=0.007) and 24% lower (P=0.056) in the individuals with the SLCO1B1*1B/*1B genotype than in those with the SLCO1B1*1A/*1A genotype. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | Plasma repaglinide and nateglinide and blood glucose concentrations were measured for 7 h. RESULTS: The AUC(0-infinity) and Cmax of repaglinide were 32% (P=0.007) and 24% lower (P=0.056) in the individuals with the SLCO1B1*1B/*1B genotype than in those with the SLCO1B1*1A/*1A genotype. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | The mean blood glucose concentration from 0 to 7 h after repaglinide intake was 10% higher in the SLCO1B1*1B/*1B participants than in the SLCO1B1*1A/*1A participants (P=0.007). | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 6 | The mean blood glucose concentration from 0 to 7 h after repaglinide intake was 10% higher in the SLCO1B1*1B/*1B participants than in the SLCO1B1*1A/*1A participants (P=0.007). | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 7 | CONCLUSION: The SLCO1B1*1B/*1B genotype is associated with reduced plasma concentrations of repaglinide, consistent with an enhanced hepatic uptake by OATP1B1, but has limited effects on the pharmacokinetics of nateglinide. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |