Title : Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.

Pub. Date : 2008 Oct 20

PMID : 18852298






1 Functional Relationships(s)
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1 Thus, we provide novel evidence that WRN is required to avoid accumulation of DSBs and fork collapse after replication perturbation, and that prompt MUS81-dependent generation of DSBs is instrumental for recovery from hydroxyurea-mediated replication arrest under such pathological conditions. dsbs WRN RecQ like helicase Homo sapiens