Title : PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways.

Pub. Date : 2008 Dec 15

PMID : 18852043

1 Functional Relationships(s)
Compound Name
Protein Name
1 Pretreating BV-2 cells with the PPARalpha agonists GW7647 and Fenofibrate significantly inhibited the radiation-induced microglial proinflammatory response, in part, via decreasing (i) the nuclear translocation of the NF-kappaB p65 subunit and (ii) phosphorylation of the c-jun subunit of AP-1 in the nucleus. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus