Title : Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.

Pub. Date : 2008 Nov 1

PMID : 18851914






1 Functional Relationships(s)
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1 A series of tetrakis-azaaromatic quaternary ammonium salts was synthesized to identify compounds with higher affinity and selectivity as antagonists at neuronal nicotinic receptor subtypes (nAChR) that mediate nicotine-evoked DA release. quaternary ammonium salts cholinergic receptor nicotinic alpha 4 subunit Homo sapiens