Title : Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.

Pub. Date : 2008 Dec

PMID : 18836030






4 Functional Relationships(s)
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1 Interestingly, CPA pretreatment significantly attenuated thrombin-induced Ca(2+) release in PASMC; this attenuation was not apparent in PAEC, indicating that a PAEC-specific mechanism was targeted by thrombin. cyclopiazonic acid coagulation factor II, thrombin Homo sapiens
2 Interestingly, CPA pretreatment significantly attenuated thrombin-induced Ca(2+) release in PASMC; this attenuation was not apparent in PAEC, indicating that a PAEC-specific mechanism was targeted by thrombin. cyclopiazonic acid coagulation factor II, thrombin Homo sapiens
3 Notably, thrombin-induced receptor-mediated calcium influx was still observed in PASMC after CPA pretreatment in the presence of extracellular Ca(2+). cyclopiazonic acid coagulation factor II, thrombin Homo sapiens
4 The data show that thrombin induces increases in intracellular calcium in PASMC and PAEC with a distinct CPA-, caffeine-, and ryanodine-insensitive release existing only in PAEC. cyclopiazonic acid coagulation factor II, thrombin Homo sapiens