Pub. Date : 2009 Jan
PMID : 18834871
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line. | Testosterone | insulin receptor | Homo sapiens |
| 2 | RESULTS: Both testosterone and 17beta-estradiol significantly increased the insulin receptor mRNA expression, cell surface insulin binding and (14)C-glucose oxidation compared to basal, but the increase was not at par with the effect of insulin. | Testosterone | insulin receptor | Homo sapiens |
| 3 | CONCLUSION: It is concluded from the present study that testosterone and 17beta-estradiol can directly enhance insulin receptor mRNA expression, insulin binding and glucose oxidation in Chang liver cells and thereby glucose metabolism. | Testosterone | insulin receptor | Homo sapiens |