Title : CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.

Pub. Date : 2009 Jan

PMID : 18832519






1 Functional Relationships(s)
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1 RESULTS: After adjustment for other predictors of patient survival, patients with CIMP-high cancers (126 (19%) tumours with >or=6/8 methylated CIMP-specific promoters) experienced a significantly low colon cancer-specific mortality (multivariate HR 0.44, 95% confidence interval (CI) 0.22 to 0.88), whereas the BRAF mutation was significantly associated with a high cancer-specific mortality (multivariate HR 1.97, 95% CI 1.13 to 3.42). Cyclic IMP B-Raf proto-oncogene, serine/threonine kinase Homo sapiens