Title : ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.

Pub. Date : 2008 Oct 1

PMID : 18829552






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Deficiencies in ATM, Mre11, or Rad50 led to a 2- to 5-fold increase in clonogenic sensitization to gemcitabine, whereas Nbs1 and H2AX deficiency did not affect reproductive growth. gemcitabine MRE11 homolog, double strand break repair nuclease Homo sapiens