Title : Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.

Pub. Date : 1991 Sep 1

PMID : 1881896






3 Functional Relationships(s)
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1 In neonatal neuron cultures, competition of 125I-AII specific binding with the above ligands revealed a potency series of CGP42112A = AII greater than [Phe(p- NH2)6]AII greater than PD123177 much greater than DuP753. PD 123177 angiotensinogen Rattus norvegicus
2 125I-AII specific binding to neonate neuronal cultures was reduced 73-84% by 1 microM PD123177, and the residual 125I-AII specific binding was eliminated by DuP753. PD 123177 angiotensinogen Rattus norvegicus
3 Also, in neuron cultures, AII induced decreases in basal cGMP that were completely blocked by PD123177 or CGP42112A but not by DuP753. PD 123177 angiotensinogen Rattus norvegicus