Title : Cardiovascular and gastrointestinal toxicity of selective cyclo-oxygenase-2 inhibitors in man.

Pub. Date : 2008 Aug

PMID : 18812633






1 Functional Relationships(s)
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1 Traditional NSAIDs inhibit the constitutional cyclooxygenase-1 (COX-1) enzyme responsible for eicosanoids biosynthesis not only in joints, a beneficial effect, but also in the stomach, a detrimental effect. Eicosanoids prostaglandin-endoperoxide synthase 1 Homo sapiens