Title : WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.

Pub. Date : 2008 Dec 1

PMID : 18805512






1 Functional Relationships(s)
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1 However, in wrn-kd but not wrn-wt cells they were converted into DNA double-strand breaks (DSBs) at high frequency, as shown by neutral comet assay and phosphorylation of H2AX. dsbs WRN RecQ like helicase Homo sapiens