Pub. Date : 2009 Jan 15
PMID : 18805405
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Furthermore, CAR and GR were also involved in the induction of CYP3A4 expression by tanshinones, though their roles seemed not as important as PXR. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Treatment of LS174T cells with cryptotanshinone or tanshinone IIA resulted in a significant increase of CYP3A4 mRNA, which was consistent with the results from the reporter gene assay. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |