Title : Differential crosstalk between P2X7 and arachidonic acid in activation of mitogen-activated protein kinases.

Pub. Date : 2008 Dec

PMID : 18804898






2 Functional Relationships(s)
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1 The results show that the synthetic P2X7 receptor agonist 2",3"-O-(4-benzoyl)benzoyl-ATP (BzATP), induced a concentration-dependent phosphorylation of MAPK ERK1/2, JNK and p38. BzATP mitogen-activated protein kinase 3 Homo sapiens
2 The potentiation of BzATP-mediated ERK1/2 phosphorylation was also observed in human embryonic kidney cells (HEK293) stably transfected with rat P2X7, but not in HEK cells expressing truncated P2X7 receptor lacking the full cytoplasmic carboxy-terminal or in those carrying the structurally related rat P2X2. BzATP mitogen-activated protein kinase 3 Homo sapiens