Title : CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.

Pub. Date : 2009 Jan 8

PMID : 18794803






1 Functional Relationships(s)
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1 Upon treatment with the CRAF inhibitor sorafenib, these lines underwent apoptosis and associated with mitochondrial depolarization and relocalization of apoptosis-inducing factor, whereas the BRAF-V600E-mutated melanomas did not. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens