Pub. Date : 2008 Sep 23
PMID : 18794531
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport. | Adenosine Triphosphate | sirtuin 3 | Mus musculus |
| 2 | We note that Sirt3(-/-) mouse embryonic fibroblasts have a reduction in basal ATP levels. | Adenosine Triphosphate | sirtuin 3 | Mus musculus |
| 3 | Furthermore in wild-type mice, the resting level of ATP correlates with organ-specific Sirt3 protein expression. | Adenosine Triphosphate | sirtuin 3 | Mus musculus |
| 4 | Remarkably, in mice lacking Sirt3, basal levels of ATP in the heart, kidney, and liver were reduced >50%. | Adenosine Triphosphate | sirtuin 3 | Mus musculus |
| 5 | These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels. | Adenosine Triphosphate | sirtuin 3 | Mus musculus |