Title : Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis.

Pub. Date : 2008 Dec

PMID : 18794357






4 Functional Relationships(s)
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Compound Name
Protein Name
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1 Treating cells with the AR ligand, dihydrotestosterone (DHT), triggered the reduction of E-cadherin expression and induced changes in cell morphology from an epithelial-like to a mesenchymal-like appearance. Dihydrotestosterone androgen receptor Mus musculus
2 Treating cells with the AR ligand, dihydrotestosterone (DHT), triggered the reduction of E-cadherin expression and induced changes in cell morphology from an epithelial-like to a mesenchymal-like appearance. Dihydrotestosterone androgen receptor Mus musculus
3 When nonmetastatic breast cancer cells expressing cytoplasmic AR were transplanted into mice and the mice were treated with DHT, tumors were detected at metastatic sites, whereas no tumors were detected in transplanted mice without DHT treatment. Dihydrotestosterone androgen receptor Mus musculus
4 When nonmetastatic breast cancer cells expressing cytoplasmic AR were transplanted into mice and the mice were treated with DHT, tumors were detected at metastatic sites, whereas no tumors were detected in transplanted mice without DHT treatment. Dihydrotestosterone androgen receptor Mus musculus