Pub. Date : 2008 Sep 15
PMID : 18794136
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 2 | We previously showed that CDDO-Me induces c-Jun NH(2)-terminal kinase (JNK)-dependent death receptor 5 (DR5) expression and augments death receptor-induced apoptosis. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 3 | We previously showed that CDDO-Me induces c-Jun NH(2)-terminal kinase (JNK)-dependent death receptor 5 (DR5) expression and augments death receptor-induced apoptosis. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 4 | The current study focused on addressing how CDDO-Me induces JNK-dependent DR5 expression. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 5 | Analysis of DR5 promoter regions defines that the CCAAT/enhancer binding protein homologous protein (CHOP) binding site is responsible for CDDO-Me-induced transactivation of the DR5 gene. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 6 | Analysis of DR5 promoter regions defines that the CCAAT/enhancer binding protein homologous protein (CHOP) binding site is responsible for CDDO-Me-induced transactivation of the DR5 gene. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 7 | Consistently, CDDO-Me induced DR5 expression and parallel CHOP up-regulation. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 8 | Blockade of CHOP up-regulation also abrogated CDDO-Me-induced DR5 expression. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 9 | These results indicate that CDDO-Me induces CHOP-dependent DR5 up-regulation. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 10 | Furthermore, salubrinal, an inhibitor of ER stress-induced apoptosis, inhibited JNK activation and up-regulation of CHOP and DR5 by CDDO-Me and protected cells from CDDO-Me-induced apoptosis. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 11 | Thus, ER stress seems to be important for CDDO-Me-induced JNK activation, CHOP and DR5 up-regulation, and apoptosis. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
| 12 | Collectively, we conclude that CDDO-Me triggers ER stress, leading to JNK-dependent, CHOP-mediated DR5 up-regulation and apoptosis. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |