Title : Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathway.

Pub. Date : 2008 Dec

PMID : 18793330






1 Functional Relationships(s)
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1 Nerve growth factor (NGF) is a trophic and survival factor for cholinergic neurons, and it induces the expression of several genes that are essential for synthesis and storage of acetylcholine (ACh), specifically choline acetyltransferase, vesicular ACh transporter (VAChT), and choline transporter. Acetylcholine choline O-acetyltransferase Rattus norvegicus