Pub. Date : 2008
PMID : 18791269
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine. | Dacarbazine | tyrosinase | Homo sapiens |
| 2 | This response sensitizes melanoma cells that overexpress tyrosinase to DTIC. | Dacarbazine | tyrosinase | Homo sapiens |
| 3 | Therefore, this study demonstrates that tyrosinase overexpression promotes an ATM-dependent p53 phosphorylation by Qct treatment and sensitizes melanoma cells to dacarbazine. | Dacarbazine | tyrosinase | Homo sapiens |
| 4 | In conclusion, these results suggest that Qct or Qct analogues may significantly improve DTIC response rates in tumors that express tyrosinase. | Dacarbazine | tyrosinase | Homo sapiens |