Title : Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients.

Pub. Date : 2008 Nov

PMID : 18790727






2 Functional Relationships(s)
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1 The number of cells in myocardial biopsies positive for p27Kip1, a protein induced by mTOR inhibition, increased in sirolimus-treated subjects (P = 0.0005) and did not change in controls (P = 0.54) suggesting sirolimus acted directly on myocardium. Sirolimus cyclin dependent kinase inhibitor 1B Homo sapiens
2 The number of cells in myocardial biopsies positive for p27Kip1, a protein induced by mTOR inhibition, increased in sirolimus-treated subjects (P = 0.0005) and did not change in controls (P = 0.54) suggesting sirolimus acted directly on myocardium. Sirolimus cyclin dependent kinase inhibitor 1B Homo sapiens