Pub. Date : 2008 Aug
PMID : 18778441
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic effect of nicotine on serotonin transporter mRNA in the raphe nucleus of rats: reversal by co-administration of bupropion. | Nicotine | solute carrier family 6 member 4 | Rattus norvegicus |
| 2 | RESULTS: Chronic nicotine infusion resulted in the reduction of 5HTT mRNA expression, which lasted through withdrawal day 2. | Nicotine | solute carrier family 6 member 4 | Rattus norvegicus |
| 3 | CONCLUSIONS: Chronic nicotine infusion reduces the synthesis of 5HTT protein, which may consequently precipitate depression during nicotine withdrawal, but co-administration of bupropion may ameliorate withdrawal symptoms by counteracting nicotine"s effect on 5HTT. | Nicotine | solute carrier family 6 member 4 | Rattus norvegicus |
| 4 | CONCLUSIONS: Chronic nicotine infusion reduces the synthesis of 5HTT protein, which may consequently precipitate depression during nicotine withdrawal, but co-administration of bupropion may ameliorate withdrawal symptoms by counteracting nicotine"s effect on 5HTT. | Nicotine | solute carrier family 6 member 4 | Rattus norvegicus |
| 5 | CONCLUSIONS: Chronic nicotine infusion reduces the synthesis of 5HTT protein, which may consequently precipitate depression during nicotine withdrawal, but co-administration of bupropion may ameliorate withdrawal symptoms by counteracting nicotine"s effect on 5HTT. | Nicotine | solute carrier family 6 member 4 | Rattus norvegicus |