Title : ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes.

Pub. Date : 2008 Nov

PMID : 18775851






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin. pifithrin mitogen activated protein kinase 3 Rattus norvegicus