Title : Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu.

Pub. Date : 2008 Dec

PMID : 18773979






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Elongation factor Tu (EF-Tu), the protein responsible for delivering aminoacyl-tRNAs (aa-tRNAs) to ribosomal A site during translation, belongs to the group of guanosine-nucleotide (GTP/GDP) binding proteins. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
2 Elongation factor Tu (EF-Tu), the protein responsible for delivering aminoacyl-tRNAs (aa-tRNAs) to ribosomal A site during translation, belongs to the group of guanosine-nucleotide (GTP/GDP) binding proteins. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
3 In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP+H(2)O-->GDP+Pi proceeds without participation of the histidine but through water molecules. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens