Title : PTEN-5-HT2C coupling: a new target for treating drug addiction.

Pub. Date : 2008

PMID : 18772044






1 Functional Relationships(s)
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1 Systemic or intra-amygdaloid application of the interfering peptide Tat-3L4F is able to disrupt PTEN coupling with 5-HT2cR in the rat VTA, resulting both in a suppression of the increased firing rate of VTA dopaminergic neurons induced by Delta 9-tetrahydrocannabinol (THC), the psychoactive ingredient of marijuana, and in a blockade of the conditioned place preference induced by THC and nicotine [Ji, S.P. Nicotine phosphatase and tensin homolog Rattus norvegicus