Title : Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition.

Pub. Date : 2008 Sep 15

PMID : 18769157






1 Functional Relationships(s)
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1 Finally, the Hsp90 inhibitor 17-AAG, by simultaneously and durably inhibiting multiple signaling activators including ErbB and Src kinases, does not permit oncogene switching and results in a more prolonged and robust inhibition of downstream signaling pathways in breast cancer cells than do individual TKIs. tanespimycin epidermal growth factor receptor Homo sapiens