Title : Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.

Pub. Date : 2008 Sep 9

PMID : 18768802






1 Functional Relationships(s)
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1 We demonstrate here that while different classes of antipsychotics have complex pharmacological profiles at G protein-dependent D2R long isoform (D2(L)R) signaling, they share the common property of antagonizing dopamine-mediated interaction of D2(L)R with beta-arrestin 2. Dopamine arrestin beta 2 Homo sapiens