Pub. Date : 2008 Sep 1
PMID : 18765530
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, 24 h after exposure, sorafenib- and vorinostat-treated cells exhibited markedly diminished expression of c-FLIP-s, full-length BID, BCL-2, BCL-XL, MCL-1, XIAP, increased expression of BIM, and increased activation of BAX, BAK, and BAD. | Sorafenib | CASP8 and FADD like apoptosis regulator | Homo sapiens |
| 2 | Expression of eIF2alpha S51A blocked sorafenib- and vorinostat-induced suppression of c-FLIP-s levels and overexpression of c-FLIP-s abolished lethality. | Sorafenib | CASP8 and FADD like apoptosis regulator | Homo sapiens |
| 3 | CONCLUSIONS: These data show that combined exposure of epithelial tumor cell types to sorafenib and vorinostat diminishes expression of multiple antiapoptotic proteins and promotes activation of the CD95 extrinsic apoptotic and the lysosomal protease pathways, and that suppression of c-FLIP-s expression represents a critical event in transduction of the proapoptotic signals from CD95 to promote mitochondrial dysfunction and death. | Sorafenib | CASP8 and FADD like apoptosis regulator | Homo sapiens |