Title : Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.

Pub. Date : 2008 Dec 1

PMID : 18729196






2 Functional Relationships(s)
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1 In vitro, extracellular acidosis (pH 6.6) activated p38 and ERK1/2 and thereby induced daunorubicin resistance via a pronounced activation of pGP. Daunorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 Intracellular acidification also induced daunorubicin resistance via activation of pGP, which was mediated by activation of p38 alone. Daunorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus