Title : Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

Pub. Date : 2008 Sep 1

PMID : 18725521






2 Functional Relationships(s)
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1 In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively. Poly C toll like receptor 4 Homo sapiens
2 In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively. Poly C toll like receptor 4 Homo sapiens