Pub. Date : 2008 Oct 31
PMID : 18718914
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, 15d-PGJ(2) activated JNK and p38 MAPK while inducing p53 phosphorylation at sites responsible for p53 activity. | 15d-pgj | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | JNK inhibitor (SP600125) or p38 MAPK inhibitor (SB203580) pretreatment attenuated 15d-PGJ(2)-mediated apoptosis and suppressed the p21(Waf1) and Bax expressions without affecting p53 protein accumulation. | 15d-pgj | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | This is the first study that 15d-PGJ(2) induces vascular endothelial cell apoptosis through the signaling of JNK and p38 MAPK-mediated p53 activation both in vitro and in vivo, further establishing the potential of 15d-PGJ(2) as an anti-angiogenesis agent. | 15d-pgj | mitogen-activated protein kinase 8 | Homo sapiens |