Title : Cl- -channel is essential for LDL-induced cell proliferation via the activation of Erk1/2 and PI3k/Akt and the upregulation of Egr-1 in human aortic smooth muscle cells.

Pub. Date : 2008 Nov 30

PMID : 18711316






1 Functional Relationships(s)
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1 Moreover, pretreatment with DIDS (Cl- channel blockers) but not LY294002 (PI3K inhibitors) completely abolished the LDL-induced upregulation of Egr-1 to the same extent as PD98059 (MEK inhibitors to inhibit Erk), as judged by Western blot and luciferase reporter assays. 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid mitogen-activated protein kinase 1 Homo sapiens